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K o<2 D #  ?{B2 D 3  ?{B2 D 3  ?uB2 D 3  ?uB2 D 3  ?uB2 D 3  ?uB2 D 3  ?uB2 D 3  ?uB2 D 3  EuB2 D 3  EuB2 D 3 }|{ EuB2 D 3 usr EuB2 D 3 kih EoB2 D 3 c`_EoB2 D 3 ZWUEoB2 D 3 PMKEoB2  D 3 FCAEoB2 !D 3 ;85EoB2 "D 3 0,)KoB2 #D 3 $!Ko<2 $D #  u B2 %D 3  u B2 &D 3  { B2 'D 3  { B2 (D 3  { B2 )D 3  { B2 *D 3  { B2 +D 3  { B2 ,D 3  { B2 -D 3  { B2 .D 3 }|{ { B2 /D 3 usr { B2 0D 3 kih { B2 1D 3 c`_ { B2 2D 3 ZWU { B2 3D 3 PMK { B2 4D 3 FCA { B2 5D 3 ;85 { B2 6D 3 0,) { B2 7D 3 $! { <2 8D #  uB2 9D 3  uB2 :D 3  {B2 ;D 3  {B2 D 3  {B2 ?D 3  {B2 @D 3  {B2 AD 3  {B2 BD 3 }|{ {B2 CD 3 usr {B2 DD 3 kih {B2 ED 3 c`_{B2 FD 3 ZWU{B2 GD 3 PMK{B2 HD 3 FCA{B2 ID 3 ;85{B2 JD 3 0,){B2 KD 3 $!{<2 LD #  B2 MD 3   B2 ND 3   B2 OD 3   B2 PD 3   B2 QD 3   B2 RD 3   B2 SD 3   B2 TD 3   B2 UD 3   B2 VD 3 }|{  B2 WD 3 usr  B2 XD 3 kih  B2 YD 3 c`_  B2 ZD 3 ZWU  B2 [D 3 PMK  B2 \D 3 FCA  B2 ]D 3 ;85  B2 ^D 3 0,)  B2 _D 3 $!  <2 `D #   B2 aD 3   B2 bD 3   B2 cD 3   B2 dD 3   B2 eD 3   B2 fD 3   B2 gD 3   B2 hD 3   B2 iD 3   B2 jD 3 }|{  B2 kD 3 usr  B2 lD 3 kih  B2 mD 3 c`_  B2 nD 3 ZWU  B2 oD 3 PMK  B2 pD 3 FCA  B2 qD 3 ;85  B2 rD 3 0,)  B2 sD 3 $!   tD BCDEF=   @`   uD BCDEF$!gg  vj$d*X0R0F6@<:B4H.T"fr  &,28DnJbPPVD\2\ bhnnttz~z`zBz$nnnBh`hxhbb\VVPJ,D>>P8\2h,t& xlZ N<"6(0.*4$@FR^d p  @` }i  vD xB$CHDEF$!$H$ @` E  qz k wD k,$D 0 xD 60׆Z   b mass spec.& G$!  yD 6܆"   bidentify( E  zD 6\ [m/z&G$!< {D # ) H |D C $!) 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"  B <h " B <k+,  " B <o| } " B BCDEF{1  @~~ B BCDEF@1 @1J B B'CDEF@1'# @ B B,CDEF@1 , @o B BCDEF@1Q @Z; T B BCCDEF@1<C @f B BnCDEF@1<n @9,E B BCDEF@1 @S] B BCDEF@1 @ B BCDEF@1o @o%  B B^CDEF@1Q^ @N B S @1 B BECDEF@1E @5N B BOC'DEF@1*'O' @Bi  B BC-DEF@1C-- @Ub !B BC%DEF@1%% @ "B B C+DEF@1+ + @Um #B BjC&DEF@1A&j& @8^ $B B?C*DEF@1M*?* @M?w %B BC0DEF@100 @m`Y &B BC:DEF@1:: @yu 'B B`CDEF@1;` @m (B BC&DEF@1'&& @0  )B BC.DEF@1.. @E& *B BC;DEF@1y;; @  H +B BCC'DEF@1C'' @xB ,B B5C7DEF@157u7 @B -B B`C`DEF@1%``` @E .B BCDEF@1 @.  /B BLC'DEF@1L'' @E 0B BWC'DEF@1'W' @<dc 1B B$C&DEF{1&$& @~ 2B BoC8DEF{1C8o8 @v 3B B\CADEF{1A\A @ 4B BC;DEF{1*;; @ 5B BCDEF{1 @0*? 6B B'CADEF{1A'A @+4 7B BCEDEF{1 EE @7X 8B B0CoDEF{10o o @76h 9B BwCDEF{1Rw @o :B B CDEF{1   @6B9 ;B BC&DEF{1&& @;*P <B BCDEF1 @^g  =B BC'DEF1'' @qt' >B BqCDEF1qj @h ?B BfCDEFpb[1f9 @7  @B BCDEFpb[1 @F H_  AB B0CDEF+10 @   BB B\CDEF+1\D @   CB BCDEF+1  @   DB BCDEF+1G @= T  FB BCDEF+1 @ m N GB S +1   HB BCDEF+1 @1 bJ N IB S +1*z   JB BC'DEF+1.'' @< c  KB B5C&DEF+1&5& @G m  LB B{C&DEF+1$&{& @ 3  MB BZCKDEF+1KZK @3Z  N NB S +1 ^  OB B^C&DEF+1;&^& @ B$  PB BCC\DEF+1(\C\ @B   QB BCDEF+1 @ ~  RB BBCDEF+1+B @.   SB B$CDEF+1 $ @   TB BCDEF+1 @f <  UB B&CDEF1& @ 2  VB BC'DEFpb[1E'' @4 /  WB BC&DEFpb[1+&& @Q uw  XB BCKDEFpb[1KXK @ d  YB B^C9DEF19^9 @A ZB BCDEF1G @A [B BCbDEF{1bb @; \B BC`DEF{1`` @ ]B BCtDEF{1tt @m ^B BCDEF{1 @qA _B BC&DEF{1&& @S `B BC*DEF{1 ** @k] aB BTCDEF{1T @vN bB S +1 m  cB BC9DEF+19u9 @N F  dB BC1DEF+111 @m   eB BC'DEF+1'' @ )  fB BCDEF+1U @A Y  gB B$CDEF+r1$ @6 \  hB BCDEF+r1 @ x  iB BCDEF+r1& @1 Z  jB B^CDEF+r1^" @P @g  kB BCDEF+r1A @   lB BCDEF+r1 @( 9  mB B<C%DEF+r1%%< @9 x  nB B4C*DEF+r1**4 @x  oB BCDEF+r1G @/F pB BC#DEF+r1## @:6] qB BC.DEF+r1..1 @Jix rB BCDEF1 @. sB BCDEF1 @w tB B=CDEF1*= @ 5$ uB BeCDEF19e @S.k vB BhCDEFDy1Gh @t wB B8C&DEF18&& @^? xB B5C0DEF1500" @+ob yB BPC$DEF1P$$ @H; zB BMC\DEF1M\\ @H& {B BQCDEF1Q @b |B BdC'DEF1d''+ @[ }B B*C8DEF188* @[ ~B BoC;DEF+r1*;;o @Jk   B B@C$DEF+r1@$$ @\ J  B BcC$DEF+1 $c$ @M q  B BQC$DEF+r1$Q$ @$ x N B S +r1x   B BCCbDEF+r1bCb @x &  B BCC$DEF+r1$C$ @2 x7 N B S +r1   B B2CDEF+r12 @=   B BCDEF+r1a @i Fa B BoCIDEF+1oIMI @ d^  B B4CDEF+14 @   B BCEDEF+1%EE @   B B=CCDEF+1dC=C @Rk   B B3C2DEF@1232 @. B B4CKDEF@1+K4K @%[ B BC}DEF@1} } @[mk B BC?DEF@1?? @]|  B BCDEF@1 @m- B BC DEF@1   @uN B S @1* B B C/DEF@1 / / @ B B\CDEF@1 \ @d9N B B.CDEF1.  @T B BCDEF1 @k   B BCDEF1 @F   B BC1DEF1`11 @ E? B BCDEF1 @  B BKCBDEF1BKB @<  B fB8CDEFDy!!"&,0468 8 8640,&"      DH@`9t B pB8CDEF1!!"&,0468 8 8640,&"      CD@9t B fB8CDEFDy!!#',046 8 88640,'#  DH@`\ B pB8CDEF1!!#',046 8 88640,'#  CD@\ B fB8CDEF!!!'*0268 88620*'!   DH@` B pB8CDEF1!!!'*0268 88620*'!   CD@ B fB7CDEF!! &,0257 77520,&    DH@` B pB7CDEF1!! &,0257 77520,&    CD@ B fB8CDEF+r!!#',0468 88640,'#   DH@`}j B pB8CDEF1!!#',0468 88640,'#   CD@}j B fB7CDEF+r!! &*.235 7 532.*&    DH@`   B pB7CDEF1!! &*.235 7 532.*&    CD@   B fB7CDEF+r!!"(,045 7 7 7540,("       DH@` $  B pB7CDEF1!!"(,045 7 7 7540,("       CD@ $  B fB7CDEF+r!! &,0267 7 7620,&    DH@` >  B pB7CDEF1!! &,0267 7 7620,&    CD@ >  B fB8CDEF+!!#&,046 8 88640,&#      DH@` *  B pB8CDEF1!!#&,046 8 88640,&#      CD@ *  B fB8CDEF+!!#&,0468 88640,&#     DH@`l *  B pB8CDEF1!!#&,0468 88640,&#     CD@l *  B fB7CDEF+!! &*.135 7531.*&    DH@`kU p  B pB7CDEF1!! &*.135 7531.*&    CD@kU p  B fB7CDEF+!! &,035 7 77530,&     DH@`m< Y  B pB7CDEF1!! &,035 7 77530,&     CD@m< Y  B fB8CDEF+!!!'+/246 8 642/+'!   DH@`$ >  B pB8CDEF1!!!'+/246 8 642/+'!   CD@$ >  B fB7CDEF+!!"(,035 7 77530,("      DH@`2k B pB7CDEF1!!"(,035 7 77530,("      CD@2k B fB8CDEF!! &*.24 6 8642.*&     DH@`7q B pB8CDEF1!! &*.24 6 8642.*&     CD@7q B fB7CDEF!! &*.24 5 7 542.*&     DH@`4Zmv B pB7CDEF1!! &*.24 5 7 542.*&     CD@4Zmv B fB8CDEF{!!!',046 8 88640,'!    DH@`08 B pB8CDEF1!!!',046 8 88640,'!    CD@08 B fB8CDEF{!!!'+.246 8 642.+'!   DH@`D2~M B pB8CDEF1!!!'+.246 8 642.+'!   CD@D2~M B fB8CDEF{!!!'-046 8 8 8640-'!    DH@`FKh B pB8CDEF1!!!'-046 8 8 8640-'!    CD@FKh B fB8CDEF@!!!',046 8 88640,'!    DH@`Ur ˆB pB8CDEF1!!!',046 8 88640,'!    CD@Ur ÈB fB8CDEF@!!#'-0468 88640-'#   DH@` ' ĈB pB8CDEF1!!#'-0468 88640-'#   CD@ ' ňB fB7CDEF@!! &*025 5 75520*&     DH@` E3 ƈB pB7CDEF1!! &*025 5 75520*&     CD@ E3 LjB fB8CDEF@!!!'*.246 8 642.*'!   DH@`0 ȈB pB8CDEF1!!!'*.246 8 642.*'!   CD@0 ɈB fB8CDEF@!!!'+.266 8 662.+'!   DH@`,f ʈB pB8CDEF1!!!'+.266 8 662.+'!   CD@,f ˈB fB8CDEF@!!#(,0468 88640,(#   DH@` ̈B pB8CDEF1!!#(,0468 88640,(#   CD@ ͈B fB8CDEF@!!!'+/266 8662/+'!   DH@`x ΈB pB8CDEF1!!!'+/266 8662/+'!   CD@x ψB fB7CDEF@!! &*.266 7662.*&    DH@` ЈB pB7CDEF1!! &*.266 7662.*&    CD@ шB fB8CDEF@!!#&,0468 88640,&#     DH@` ҈B pB8CDEF1!!#&,0468 88640,&#     CD@ ӈB fB7CDEF@!!"&,0457 7 7540,&"      DH@`4m ԈB pB7CDEF1!!"&,0457 7 7540,&"      CD@4m ՈB fB8CDEFpb[!!!'+.24 6 8642.+'!    DH@`, f#  ֈB pB8CDEF1!!!'+.24 6 8642.+'!    CD@, f#   B/CRDE$F0? 00 0/(R@`@`|  BvCRDE$F0 122 1 12v*R@`@`A4  BCSDE$F0(o 22!!2+S@`@`5O   BuCSDE$F0ľ /22!/!/2u+S@`@`{J  BACRDE$F0Ex 22""2A*R@`@`e   BCTDE$F0ľ F22"F"F2 * T @`@`JH  C Ex r    BeClDEFExehVl @`x mH  C T C R   BCDEF  @`eP H  C ? ,  BSCDEF?OS  @`+~H  C ľ     BCDEFľ  @`  H ‹ C ľ   Ë BCDEFľ @`  H ċ C (oC   ŋ B1CDEF(o&1  @` ; @ L C  @ L C Hu   L <t   \E-64&G  L < m 'Arabidopsis: ~30 papain-like proteases ((G( L <෋  . ^biotin&G  L BC DEF$!   @`q1C} L B CDEF$!   @`_%1q L BC DEF$!   @`S%_@B L C $! @B L C $! @B L C $! @B L C $! @B L C $!  L zBCDE F$!  @ L BCDEF&$!    @`) ;@B L C $! ;}@B L C $! ) ;@B L C $!  ;@B L C $! e k@B L C $! _ e@B L C $! Y _@B L C $! S Y@B L C $! M S@B L C $! G M@B L C $!   L ~B@CDEF&$! AA?67@?667667.-67.---.-$%.-$$%$$%$%          @`@`@`@`@`@`@`@`@`@`@`@`@`w   L B5C DEF$! --5, + 45, , + , , + "#, + ########     dh@`@`@`@`@`@`@`@`@`YkV L .BCDEdFv$!      8<@`@`@`@`@`we V L .BCDEdFv$!           8<@`@`@`@`@`w L B-CDEF$! ---$#,-$$#$$#$#     dh@`@`@`@`@`@`@`@`@`q  L B C DEF$!    @` L B C DEF$!    @`  L BCDEF$!    @`w R L *B7CDEF$! 77     %$%$$$%$-.%$--.--.76-.z|@`@`@`@`@`@`@`@`@`@`@`qW  L <ŋ }  [N(G L <ʋ   [H(G L <΋ 5e  [H(G L <<Ӌ ee  [N(G L <׋  +  \OH(G L <܋  ' L [O(G L <  C  [O(G L < [ [O(G L <l 3eL [O(G L < . [O(G L <L Ye ]EtO(G L <  F [O(G L <, ' Y 4 [O(G L B V+] [O(G L B CDEF$!    @`#W G L B CDEF$!    @`] ;@ L C $! A  }@ L C $!  ) @ L C $! 1@ L C $! am@ L C $! A?K}@ L C $! )e@ L C $! A }@ L C $! %9Kg@ L C $! A }@ L C $! / ; @ L C $! s@ L C $! AQ]}@ L C $! )e L B C DEF$!    @`_k L B C DEF$!    @`kw L B CDEF$!   @`w}@ L C $! A }@ M C $! %K]g( M BCDEF$! 22      op@`@`@`@`@`@`@`@`@`@`k M BCDEF$!    @`E]1 M BCDEF$!    @`]u M BCDEF$!    @`o M BCDEF$!   @`c{@ M C $! Qc@ M C $! 3? M BCDEF$!  @`3  M BCDEF$!    @`'   M BCDEF$!    @` !9  M BCDEF"$!  @`9Q1  M xB CDEF$!   @`1EQ7  M BC DE<FJ$!       "$@`@`@`7@2 M C Hu 9%@2 M C Hu ]%@2 M C Hu Y-c M B8 N2] [S(G M <  /0 \HN(G M < c6 \NH(G M <p  I  [N(G M <#  I  [H(G M <P(  + @ \NH(G M <, ) D ? [2(G M <01  [N(G M <5  [H(G M <: j [H(G M <> M [N(G M B C DEFz$! tt                                                     @`@  `@`@  `@`@`@  `@  `@`@`@  `@  `@`@`@  `@  `@`; ) M <B )'v [O(G^ !M 68Gx| D,$ 0 0labeling reflects activity rather than abundanceL1 E$!E$!E$!$ "M 6 N%  TDCG-04GH  0޽h ? LxdR , TIMING|11.3|26 ___PPT10 .*+eFDS ' = @B D ' = @BA?%,( < +O%,( < +Ds' =%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*#M%(D' =-g6B fade*<3<*#MD' =%(D8' =A@BB BB0B%(D' =1:Bvisible*o3>+B#style.visibility<*!M%(D' =-g6B fade*<3<*!MD' =%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<* M%(D' =-g6B fade*<3<* MD' =%(D' =%(D7' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*Ƌ%(D' =-s6Bwipe(left)*<3<*Ƌ+8+0+!M +oZK0 @9(  8N 8 C &AAtPst3 8 c $X99?<k,$D 0 8 BCCDEDF.ȉ! #4CC!CC4# !@    `B`,$D 0& 8 6(](q,$ 0 2 what mechanisms occur at protease activity level?(32E3L 8 c $X99? 9 TLb 1 ))?H gPseudomonas - ArabidopsisH 8 0޽h ? LxdR 0 TIMING|17.3|40.9 ___PPT10 +sHD4 ' = @B D' = @BA?%,( < +O%,( < +D&' =%(%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*8%(D' =-g6B fade*<3<*8D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*8%(D' =-g6B fade*<3<*8D' =%(D@' =A@BB BB0B%(D' =1:Bvisible*o3>+B#style.visibility<*8%(D' =-o6Bdissolve*<3<*8+8+0+8 +:ZK0 Eq=q8֑@p(  ! ѐ TTm 1 ))?H Infection of plant cell culture <     BdCDEFDD" " """ "  !!""                ""!! """"""BB""BBBBBBCDEDCCBBEFGGDDDDEGGDDGGGDDGGGFEDDDDGEDC B BCCDEB B BBB AABBACC,A,ACA-A,A,B,A-C,dbA-C,ddccdccbccbabcbddbbdddcdddbbdddcdddbbdddcdddddbbbbdddbbdddb`^`bbd`]ZVVY\^`VVVVVV33VV30033000  !,#-#,#,#-",#,!,!##,!,"##"">@@`@  `@`@  `@`@`@  `@`@  `@`@`@`@  `@  `@`@`@  `@  `@`@`@`@`@`@`@`@`@`@`@`@`@`@`@  `@`@  `@  `@`@`@`@`@`@  `@  `@`@`@  `@  `@  `@`@`@`@`@`1 K   BeCDEFp@@" " """ " ! !!"""    !    !    !"""!!""""""CC""CCCCCCDEFDDCCCFGGGEEEDFGGEEGGGEEGGGGFDEEEGFED C CCDDFC C CCC AACCADD,A,ADB-A,A,C,B-D,dbB-D,dedcddcccdbbccbddbbdddcdddbbdddcdddbbdddcdddddbbbbdddbbdddc`_abbd`^ZVVZ]_`VVVVVV44VV41144111  !,#-#,#,#-",#,!,!##,!,"##""58@`@  `@  `@`@`@  `@  `@`@`@`@  `@  `@`@`@  `@  `@`@`@`@`@`@`@`@`@`@`@`@`@`@`@  `@`@  `@  `@`@`@`@`@`@  `@  `@`@`@  `@  `@`@  `@`@`@`@`@`} K  BZC DE,F& ZZU N . +  Z@  ` 3  BZC DE,F& ZZU O / ,  Z@  ` 3_l  mo  ֑m o ,$D 0   j BJCODEPF                                           G+E-G+H+G-F,G+G-G-E+E+G-E-D,E+F,E-G+G+E-E-G+G+G+F,G+G+G+E-E-G+G+G+F,G+G+G+E-E-G+G+G+F,G+G+G+G+H,E-E-E-E-G+E-E-F,E-H,H,E-E-H,H,H,F,H,H,H,H-H-F.F.F.E-H,H-I.I.I/F/F/F/F.H-I/J1I5F6E4F3G1F/I/F69A7?E4F69A8B6@7?9A8B*M)K6@8B)K)K*L)K*M*M)K)K*M*M*M*L*M*M)O'O%O%L&L(L)K*M%O#O!N L"J#K$L%L%O L L!K L L L"J"J L"J"J!K"J L L"J"J L L L!K L L LLL"J"J"J"J L"J"J K"JLLKK!J!J"J"JLKK KKKKJI!H!I!I!JK!H!H!HI!HI!HI   @`@`@  `@  `@`@`@`@`@`@  `@  `@`@`@`@`@`@`@`@  `@  `@  `@`@`@`@  `@  `@`@`@`@`@`@`@`@`@`@`@`@`@`@`@`@  `@`@`@`@  `@  `@  `@`@`@`@`@`@`@  `@  `@`@`@`@`@`@  `@`@  `@`@  `@`@`@`@`@` o w   j BJCODEPF                                           G+E-G+H+G-F,G+G-G-E+E+G-E-D,E+F,E-G+G+E-E-G+G+G+F,G+G+G+E-E-G+G+G+F,G+G+G+E-E-G+G+G+F,G+G+G+G+H,E-E-E-E-G+E-E-F,E-H,H,E-E-H,H,H,F,H,H,H,H-H-F.F.F.E-H,H-I.I.I/F/F/F/F.H-I/J1I5F6E4F3G1F/I/F69A7?E4F69A8B6@7?9A8B*M)K6@8B)K)K*L)K*M*M)K)K*M*M*M*L*M*M)O'O%O%L&L(L)K*M%O#O!N L"J#K$L%L%O L L!K L L L"J"J L"J"J!K"J L L"J"J L L L!K L L LLL"J"J"J"J L"J"J K"JLLKK!J!J"J"JLKK KKKKJI!H!I!I!JK!H!H!HI!HI!HI   @`@`@  `@  `@`@`@`@`@`@  `@  `@`@`@`@`@`@`@`@  `@  `@  `@`@`@`@  `@  `@`@`@`@`@`@`@`@`@`@`@`@`@`@`@`@  `@`@`@`@  `@  `@  `@`@`@`@`@`@`@  `@  `@`@`@`@`@`@  `@`@  `@`@  `@`@`@`@`@` o w  B.CDE,F& &.  @  `U i e@  BC"DE\FfWW"h$&**06<BrHZTBZ<Z0`*f$lrx~  $*6BNZl,~8JVz,,h\J8~,l ZH<0$ xrl `ZTN$H0B6BB6Z0r*$& h""@` m   xBHCDEFHH @` G   <tu m>  [vir&G$!> l gm: Ցmg:,$D 0   j BICODEPF                                         F+E-F+G+G-F,F+G-G-D+D+G-E-D,D+E,E-F+F+E-E-F+F+F+E,F+F+F+E-E-F+F+F+F,F+F+G+E-E-F+G+G+F,G+G+G+G+G,E-E-E-E-G+E-E-F,E-G,G,E-E-G,G,G,F,G,G,G,H-H-F.E.E.E-G,H-H.H.H/F/F/F/F.H-H/I1H5F6D4F3F1F/H/F69A7?D4F69A7B6@7?9A7B*M(K6@7B(K(K)L(K*M*M(K(K*M*M*M)L*M*M(O&O$O%L&L'L(K*M$O"O NL!J"K#L%L$OLL KLLL!J!JL!J!J K!JLL!J!JLLL KLLLLL!J!J!J!JL!J!J K!JLLKK!J!J!J!JLKK KKKKJI H I!I!JK H H HI HI HI   @`@`@  `@  `@`@`@`@`@`@  `@  `@`@`@`@`@`@`@`@  `@  `@  `@`@`@`@  `@  `@`@`@`@`@`@`@`@`@`@`@`@`@`@`@`@  `@`@`@`@  `@  `@  `@`@`@`@`@`@`@  `@  `@`@`@`@`@`@  `@`@  `@`@  `@`@`@`@`@`]w   j BICODEPF                                         F+E-F+G+G-F,F+G-G-D+D+G-E-D,D+E,E-F+F+E-E-F+F+F+E,F+F+F+E-E-F+F+F+F,F+F+G+E-E-F+G+G+F,G+G+G+G+G,E-E-E-E-G+E-E-F,E-G,G,E-E-G,G,G,F,G,G,G,H-H-F.E.E.E-G,H-H.H.H/F/F/F/F.H-H/I1H5F6D4F3F1F/H/F69A7?D4F69A7B6@7?9A7B*M(K6@7B(K(K)L(K*M*M(K(K*M*M*M)L*M*M(O&O$O%L&L'L(K*M$O"O NL!J"K#L%L$OLL KLLL!J!JL!J!J K!JLL!J!JLLL KLLLLL!J!J!J!JL!J!J K!JLLKK!J!J!J!JLKK KKKKJI H I!I!JK H H HI HI HI   @`@`@  `@  `@`@`@`@`@`@  `@  `@`@`@`@`@`@`@`@  `@  `@  `@`@`@`@  `@  `@`@`@`@`@`@`@`@`@`@`@`@`@`@`@`@  `@`@`@`@  `@  `@  `@`@`@`@`@`@`@  `@  `@`@`@`@`@`@  `@`@  `@`@  `@`@`@`@`@`]w  B-CDE,F& &- @  ` e@  BC"DE\FfWW"h$&$*006BrHZNBT<Z0`*f$lrx~  $*6BNZl&~8DVz,,hVD8~&lZH<0$ xlf `ZTN$H0B6<B6Z*r$ & h""@`m/  xBHCDEFHH @`gG  <{;: c avrRpm1 ( G$!   <xAm [avr&G$!8 s.4 ԑs.4  <|s*  e Arabidopsis( G$!   <=. d cell culture& G$!   <i+4 (Rpm1)LG$!G$!G$!4  <@Mu ,$ 0 + Pseudomonas bacteriaLG$! G$! G$!  <9w ,$ 0 ` defence& G$!   <89y ,$ 0 b disease& G$! l   ӑ S_,$D 0  < T  ]vir(G$!  <L   Z10&G$!  <   [100&G$!  <, ^  Z50&G$!  <my & Y0&G$!  <  ?  Z24&G$!  <|C Z10&G$!  <ˆK Z24&G$!  <\Lj   ^(hour)&G$!H  C $!S m H ‘ C $!9 S H Ñ C $!'I ; H đ C $!  '  ő <̈   d % cell death& G$!  Ƒ BHCDEF$!((FFHHFFHCCHHCFHHFFFFFY\@`@`@`@`@`@`@`@`=  H Ǒ C $!  # H ȑ C $!  H ɑ C $!=  U  ʑ BCDETFB$! @  `@`@  `O   ˑ BCDETFB$! @  `@`@  `i   ̑ BCDETFB$! @  `@`@  `   ͑ BCDETFB$! @  `@`@  ` % NB Α S $!o  NB ϑ S $!o = NB Б S $!o NB ё S $!o  ґ <8Ԉ <  ]avr(GH  0޽h ? LxdR2 TIMING|18|5.4|3.8C___PPT10#.*+cbDO' = @B D ' = @BA?%,( < +O%,( < +DV ' =%(D' =%(D@' =A@BB BB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-o6Bdissolve*<3<*D' =%(D3' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*֑%(D' =-o6Bdissolve*<3<*֑D' =%(D@' =A@BB BB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-o6Bdissolve*<3<*D' =%(D3' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*Ց%(D' =-o6Bdissolve*<3<*ՑD' =%(D@' =A@BB BB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-o6Bdissolve*<3<*D' =%(D' =%(D3' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*ӑ%(D' =-o6Bdissolve*<3<*ӑ++0+ ++0+ ++0+ +ZzZK0 __l, (_(    T 1 ))?H n differential protease activities!!  ? BCCDEDF.ȉ i! "4C!CiC{C4" {i@    `IM,$D  0 @ <@  & RD21: Responsive to Dessiccation-21T' AA AAA't P C IU,$D 0l   y ,$D 0  N <  14 hour in vivo labelingLG$!G$! G$!H Q C = 28 3wcH |w3cHN A S [wN B S w[N C S ]wN D S wAN E S `]\Aw F <=H Y0&G$! G < 3H ]time:&G$! H < S  H Z10&G$! I < KH Z24&G$! J < acH \(hr)&G$!N O S $!wN R S $!wN S S $!qwN T S $! w N U S $! w N V S $!kwN W S $!wN X S $! w# N Y S $! wM N Z S $!wUN [ S $!wN \ S $!9 w N ] S $!M w N ^ S $!wN _ S $!+wN ` S $!wqN a S $! w N b S $! wc N c S $!wkN d S $!w+N e S $!wN f S $!# w N g S $!c w N h S $!UwN i S $!1wN j S $!w9 N k S $! w1hl 5w {5w,$D  0 K < 5b x +Pseudomonas: G$! G$! H l C I i/ m xBTCDEFIT*T @`9wOl u  w zu w,$D  0 L < u  b _+DCG-04&G$!H n C = i / o xBTCDEF=T*T @`k  wOl  },$D 0 M < % b _extract&G$!H p C $! q xBTCDEF$!*T @`Ql   , ,$D 0H  C A   F H  C A   F   B,CDEF$! ((++,,++,)),,)+,,+++++Y\@`@`@`@`@`@`@`@` F   B-CDEF$! ((++++++--++--**---++-Y\@`@`@`@`@`@`@`@` F   <+  F   svir Pst:G$!G$!  <0  . i  c anti-biotin& G$!  Ï <T5  m9 \MW(G  ď <X9  . \pI(G  ŏ <`7  6   savr Pst:G$!G$! Ə <pB   ~  Z26&G$! Ǐ <F  hx Z37&G$! ȏ <E  l Y3&G$! ɏ <pI   l  Y3&G$! ʏ <hM   la  Y7&G$! ˏ <|Q  lc Y7&G$!H ̏ C $! v  H ͏ C $! vH  C  0  xBTCDEF T*T @`b. H  C  *B<  xB~CTDEF ~*T @`ZZ2  s *Hu$!o P>Z2  s *$!o P < Z2  s *4p$!o P  H  C $! * H  C $! , I0l t }    ,$D  0 Ώ <p^  t }  \RD21&G$! Ϗ <b   }  a RD21-like& G$!  Џ BCDEF   @`@   я BC$DEF EE    $ $$$$$$$           @`   ҏ B$CDEF EE$$$                $@`   ӏ BC$DEF EE$$$$                        $ $ $$@`   ԏ pB$CDE F CC        $$$$$$            @`   Տ BCDEF   @`@ 0  ֏ BC*DEF EE $ $ $ $ $ $$$*           @` *$  ׏ B$CDEF EE$$$$                $@` 6  ؏ BC$DEF EE$$$$                                     $@`0 N  ُ pB*CDE F CC    $$$$ $ $ $ **              @`$ N$  ڏ BCDEFI   @`0   ۏ B$CDEFI EE         $$$$$$            @`$ <  ܏ BC*DEFI EE       $$$$* $ $ $             @` *  ݏ B*CDEFI EE****$$ $ $ $ $ $   *@`   ޏ pBC*DE FI CC***** $ $ $ $ $$            *@` <  ߏ BVCDEFI JV  @`T6    B*CDEFI EE         $$$$**$$ @`60 `H   BC*DEFI EE  $$$$$* $                          @`6 N6   B*CDEFI EE****** $ $ $ $ $ $           *@`B l   pBC*DE FI CC**** $ $ $ $ $$             *@`Z rB H  0޽h ? LxdRF TIMING*|2.4|6.3|5.3|12.7|4.4___PPT10.*+D|' = @B D7' = @BA?%,( < +O%,( < +D ' =%(%(D' =%(D' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*{%(D' =+4 8?\CB#ppt_xBCB#ppt_xB*Y3>B ppt_x<*{D' =+4 8?dCB0-#ppt_h/2BCB#ppt_yB*Y3>B ppt_y<*{D' =%(D3' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*P%(D' =-o6Bdissolve*<3<*PD' =%(D' =4@BBBB%(D' =1:Bvisible*o3>+B#style.visibility<*z%(D' =+4 8?\CB#ppt_xBCB#ppt_xB*Y3>B ppt_x<*zD' =+4 8?dCB0-#ppt_h/2BCB#ppt_yB*Y3>B ppt_y<*zD' =%(D3' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*y%(D' =-o6Bdissolve*<3<*yD ' =%(D' =%(D3' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*}%(D' =-o6Bdissolve*<3<*}D' =%(D3' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-o6Bdissolve*<3<*D' =%(D3' =4@BB BB%( D' =1:Bvisible*o3>+B#style.visibility<*%(D' =-o6Bdissolve*<3<*D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*?%(D' =-g6B fade*<3<*?+ KZK0 3+kx?PT g(  0 0 6  ,$ 0 JRD21 activity: %z x V'< 0  ,$D 0 0 6 x V'<  induced by avr Pseudomonas2   0 fBCDEFDy!!Xjy'6FWhyyjXG6'yhWF6''6GXDH@` |4 + 0 fBCDEFK}!!Tfu%2BSdsufTC4$sdSB2%$4CTDH@` ~4 % 0 fBCDEFQ!!P`o|%2BQbp|o`PA2$ pbQB2 %$2APDH@` ~2   0 fBCDEFX!!M]lw#0>M\lywl]M>0#yl\M>0##0>MDH@` 0   0 fBCDEF]!!IYfq}!,<IXfs}}qfYI<,!}sfXI<,!!,<IDH@` .   0 fBCDEFd!!ET`m w*8EU`lwwm`TE8*w l`UE8*  *8EDH@` .   0 fBCDEFj!!AN\g qy~(4AO~\yfqqgy\NA5(yq f\OA4(  (5ADH@` ,   0 fB|C}DEFq!!?JVa ksx&z2|=zKxVs`kiaqVwJ{?}1{&wqi `VK=2&  &1?DH@` *  0 fBuCuDEFw!!<GS\ dlq"u.u9uEqPlZdd\kSqGs<u0s%qkd ZPE9."  %0<DH@` (  0 fBoCmDEF~!!8CMV^fj m,o6mAjKfT^^VdMiCk8m,k#id^ TKA6, #,8DH@` (  0 fBgCgDEF!!4=GP X^d e*g4e?dI^PXXP`Gd=g4g*gd`X PI?4*  *4DH@` &  0 fB_C`DEFÎ!!09CJ RX\_&_0_9\CXKRRJXC\9`0`&`\X RKC90&  &0DH@` $  0 fBYCXDEFɖ!!,6>EM QWY$Y,Y5W=QEMLER>V6X,X%XVRLE=5,$ %,DH@` #  0 fBSCRDEF͝!!(2:?E KOQ S(Q1O9K?EE?J:N2P(R!PNJ E?91(  !(DH@` #  0 fBKCKDEFԧ!!$,49? EGIK%I-G4E:?@9D4G,I$KIGD @:4-% $DH@` !  0 fBCCDDEFڱ!!"(.39 =ACC!C)A.=49:3>.B(D"DDB> :4.)! "DH@`   0 fB<C<DEF߼!!%+.48:<<<%:)8.42.6+:%<<<:6 2.)% DH@`   0 fB6C4DEF!!!%(.0 44644%0).,(0%2!4442 0,)%  DH@`   0 fB.C.DEF!! $&* ,...,!*%&)$* ,... , *)%!   DH@`   0 fB&C'DEF!! " $ &&&$" #%'''' '%#   DH@`   0 fBC!DEF!!  !      DH@`   0 fBCDEF!!       DH@`  %z x c6I 0  ,$D 0 0 6 x c6I ! suppressed by vir Pseudomonas2"   0 fBCDEFDy!!Xjy &4EVhyyjXG6'yhVE4&' 6GXDH@` 4 : 0 fBCDEFK}!!Tfu $2ASdsufTC4$sdSA2$$ 4CTDH@` 4 4  0 fBCDEFQ!!P`o|$2AQbo|o`PA2$ obQA2 $$2APDH@` 2 . !0 fBCDEFX!!M]lw "0=M\kywl]M>0#yk\M=0"# 0>MDH@` 0 ( "0 fBCDEF]!!IYfq } ,;IXfs}}qfYI<,!}sfXI;, ! ,<IDH@` . # #0 fBCDEFd!!ET`m w*7ET`kwwm~`TE8*~w k`TE7*  *8EDH@` .  $0 fBCDEFj!!AN\g qy~(3AN~\yeqqgy\~NA5(~yq e\NA3(  (5ADH@` ,  %0 fB|C|DEFq!!?JVa ksx&z1|=zJxVs`kiaqVwJz?|1z&wqi `VJ=1&  &1?DH@` *  &0 fBuCvDEFw!!<GS\ dlq#u/u:uFqQl[dd\lSpGt<v0t%pld [QF:/#  %0<DH@` (  '0 fBoCnDEF~!!8CMV^fj!m+o6mBjKfU^^VdMjCl8n,l#jd^ UKB6+! #,8DH@` (  (0 fBgChDEF!!4=GP X^d!e+g4e@dI^QXYP`Gd=h4h*hd`Y QI@4+!  *4DH@` &  )0 fB_C`DEFÎ!!09CJ RX\_'_0_:\DXKRSJYC\9`0`&`\Y SKD:0'  &0DH@` $  *0 fBYCYDEFɖ!!,6>EMQWY%Y,Y6W>QEMMEQ>W6Y,Y%YWQME>6,%%,DH@` #  +0 fBSCSDEF͝!!(2:?E KOQ!S(Q2O:K@EE?K:O2Q(S!QOK E@:2(! !(DH@` #  ,0 fBKCKDEFԧ!!$,49? EGIK%I,G4E:??9C4G,I$KIGC ?:4,% $DH@` !  -0 fBCCCDEFڱ!!"(.39 =ACC!C(A.=49:3=.?(C"CC?= :4.(! "DH@`   .0 fB<C;DEF߼!!%+.48 :<<<":(8.42.6+:%;;;:6 2.(" DH@`   /0 fB6C4DEF!!!%(.0 44644$0(.,(0%2!4442 0,($  DH@`   00 fB.C.DEF!! $&* ,..., *$&($* ,... , *($    DH@`   10 fB&C&DEF!! " $ &&&$" $&&&& &$    DH@`   20 fBC DEF!!        DH@`   30 fBCDEF!!       DH@`  $z x nT 40  x,$D 0 50 6 x nT ^" post-translational suppression #" 60 fBCDEFDy!!Xjy &4EVgyyjXG6'ygVE4&' 6GXDH@` 4 H 70 fBCDEFK}!!Tfu&4CTeuufTC4$ueTC4&$4CTDH@` 4 C 80 fBCDEFQ!!P`o|$2APbo~|o`PA2$ ~obPA2 $$2APDH@` 2 = 90 fBCDEFX!!M]lw "0=L\kxwl]M>0#xk\L=0"# 0>MDH@` 0 7 :0 fBCDEF]!!IYfq}!-<IYfr}}qfYI<,!}rfYI<-!!,<IDH@` . 1 ;0 fBCDEFd!!ET`m w+8EU`lwwm`TE8*w l`UE8+  *8EDH@` . , <0 fBCDEFj!!AN\g qy~)4BO~\yfqrgy\NA5(yr f\OB4)  (5ADH@` , ( =0 fB|C}DEFq!!?JVa ksx'z2|>zKxWs`kjaqVwJ{?}1{&wqj `WK>2'  &1?DH@` * " >0 fBuCuDEFw!!<GS\ dlq#u.u:uEqQlZdd\lSoGs<u0s%old ZQE:.#  %0<DH@` (  ?0 fBoCmDEF~!!8CMV^fj!m*o6mAjKfU^^VdMjCl8m,l#jd^ UKA6*! #,8DH@` (  @0 fBgChDEF!!4=GP X^d!e*g4e?dI^QXXP`Gd=h4h*hd`X QI?4*!  *4DH@` &  A0 fB_C`DEFÎ!!09CJ RX\_&_0_:\CXKRSJXC\9`0`&`\X SKC:0&  &0DH@` $  B0 fBYCXDEFɖ!!,6>EM QWY$Y,Y6W=QEMMEQ>V6X,X%XVQME=6,$ %,DH@` #  C0 fBSCRDEF͝!!(2:?E KOQ S(Q2O9K?EE?K:O2P(R!POK E?92(  !(DH@` #  D0 fBKCKDEFԧ!!$,49? EGIK$I,G4E9??9C4G,I$KIGC ?94,$ $DH@` !  E0 fBCCCDEFڱ!!"(.39 =ACC C(A.=3993=.?(C"CC?= 93.(  "DH@`   F0 fB<C;DEF߼!!%+.48 :<<<":(8.41.5+9%;;;95 1.(" DH@`   G0 fB6C3DEF!!!%(.0 44644$0(.,(/%1!3331 /,($  DH@`   H0 fB.C.DEF!! $&* ,..., *$&($* ,... , *($    DH@`   I0 fB&C'DEF!! " $ &&&$" !%'''' '%!   DH@`   J0 fBC!DEF!! !     DH@`   K0 fBCDEF!!       DH@`   H> T  1 ))?H    "? 6$ U P +RD21 antibody: Ikuko Hara-Nishimura (Kyoto)4, .? B+CbDEDF.ȉ! ++!+A+Sb b!bbSA!!@    `  ,$D  0:2 /? 3  )c  1? <    / role for RD21 in plant-pathogen interactions? 0/A0l )   4? ) ,$D  0B2 0? 3  ) _  2? <     4 illustrates potential of activity-based approaches 54A5l ` u?,$D 0H _? C Ap2 `? B7CLDEF$!''I6I6LLI7J7L6L6J7J6J677J6J67766666JJLLJJLWX@`@`@`@`@`@`@`@`j2 b? < $+ ^active&G$! c? <\ " \RD21&G$! f? < ` hbiotin pull-down&G$! g? < ] [ctr&G$! l? BCDEF=   @`+ s? < c& a anti-RD21& G$! l 2 v??c,$D 0H a? C Ap2 h? < A] [avr&G$! i? < b] [vir&G$! j? < D ^24 hpi&G$!H n? C $!H o? C $!jvH p? C $! 2H q? C $!p&l    x?Q ,$D 0 d? < _&  ]total&G$! e? <$ (  \RD21&G$!H k? C A   m? BCDEF=   @`+I  r? BCQDEF$!((QQOOQQQPPQPPPPPPQQPPY\@`@`@`@`@`@`@`@`   t? < c   a anti-RD21& G$! H 0 0޽h ? 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"Chemetics":$EEx JB <( j W $E0 KB <0- rg,$  0 8use chemicals to identify functions of enzyme activities&98G9sl J CJ,$D 0 LB <1 J0 +2. Determine the function of these enzymes:$,+EEx, MB <5 -  . by traditional reverse genetics... &/.G/l &_ C&_,$D 0 NB <: & 61. Discover more enzymes with differential activities:$76EEx7 OB <@B &i_ C using other probes on Arabidopsis - Pseudomonas interaction&DCGDT:l D   C  ,$D 0H iC C D  9@ ; D  C; D  mC B$C7DEF))77620 *&$  "$"   sX@*  $ &**0@2X6s77TX@`; _ D  pC B#C7DEF))77620 *&$  "#"   uX?*  $ &**0?2X6u77TX@` D  qC B$C7DEF))77620 *&$  "$"   uY@+  $ &*+0@2Y6u77TX@`  D  rC B$C7DEF))77620 *&$  $$$   uXA*  $ &**0A2X6u77TX@`6 Z D  sC B$C7DEF))77620 *&$" $$$"  u[B,  $ &*,0B2[6u77TX@` D  tC B$C7DEF))77620 *&$" $$$"  uZA,  $ &*,0A2Z6u77TX@`1 UD  uC B"C7DEF))77620 *&$  """   sX?*  $ &**0?2X6s77TX@` D P vC B$C$DEdFn$"  $  X*  *X"$48@`; _ P yC B#C$DEdFn$"  #  X*  *X"$48@` P zC B$C$DEdFn$"  $  Y+  +Y"$48@`  P {C B$C$DEdFn$"  $  X*  *X"$48@`6 Z P |C B#C$DEdFn$"  #  Z*  *Z"$48@`  P }C B$C$DEdFn$" "$" Z,  ,Z"$48@`1 U P ~C B"C$DEdFn$"  "  Y+  +Y"$48@`  P C B"C$DEdFn$"  "  X*  *X"$48@`  P C B$C$DEdFn$"  $  X*  *X"$48@`;h _ P C B#C$DEdFn$"  #  Z*  *Z"$48@` h  P C B$C$DEdFn$" "$" [,  ,["$48@`h  P C B$C$DEdFn$" "$" Z,  ,Z"$48@`1h U P C B$C%DEdFn%#  $  X*  *X#%48@`;( _ M P C B#C%DEdFn%#  #  X*  *X#%48@` ( M P C B$C%DEdFn%#  $  Y+  +Y#%48@` (  M P C B$C%DEdFn%#  $  X*  *X#%48@`6 ( Z M P C B#C%DEdFn%#  #  Z*  *Z#%48@` ( M P C B$C%DEdFn%# "$" [,  ,[#%48@`( M P C B$C%DEdFn%# "$" Z,  ,Z#%48@`1( UM P C B"C%DEdFn%#  "  Y+  +Y#%48@`( M P C B"C%DEdFn%#  "  X*  *X#%48@`( M P C B$C%DEdFn%#  $   Y+  +Y#%48@`  P C B$C%DEdFn%#  $   X*  *X#%48@`6 Z P C B#C%DEdFn%#  #   Z*  *Z#%48@`  P C B$C%DEdFn%# "$"  [,  ,[#%48@`  P C B$C%DEdFn%# "$"  Z,  ,Z#%48@`1 U P C B"C%DEdFn%#  "   Y+  +Y#%48@`  P C B"C%DEdFn%#  "   X*  *X#%48@`  P C B$C$DEdFn$"  $   X*  *X"$48@`; _ P C B#C$DEdFn$"  #   X*  *X"$48@` P C B$C$DEdFn$"  $   Y+  +Y"$48@`  P C B"C$DEdFn$"  "   Y+  +Y"$48@`  P C B"C$DEdFn$"  "   X*  *X"$48@`  *l o   Ch o _ ,$@ 0  C BPChDEF)) 3C!I%L+N.P4N:L@IDCI3QY`dhhhfdI`0YQ ID@:4.+% !0I fTX@`x     C BPChDEFg )) 3C!I%L+N.P4N:L@IDCI3QY`dhhhfdI`0YQ ID@:4.+% !0I fST@x    C BPChDEF)) 3C!H%L+P.P4P:L@HDCI3Q Y`dhhhhdK`2YQID@:4.+%!2K hTX@`s   C BPChDEFg )) 3C!H%L+P.P4P:L@HDCI3Q Y`dhhhhdK`2YQID@:4.+%!2K hST@s  Z C *BPC5DEdFlg P3P3P3N0L*I$C 3 fI 0 $*035534@x  : Z C *BPC5DEdFlg P3P3P3P0L*H$C 3  hK 2 $*035534@s :  $C BCDEDFN 4Uu uU4 $(@` )  'C BCDEDFN 4Uu uU4 $(@` $  8C `BChDEF!!GWd r}'{0n:`DQMBW4]'bfhfd`[S IB8+-8#GDH@` >  ;C `BChDEF!!GWd q}'y0n:`DQMAW2]'bfhfd`[S IB8(-8#GDH@` >  CC `BChDEF!!PA2 $ '0(:5DEMTWc]qb|fhfd`[SIBy8m-^#PDH@` >  FC `BChDEF!!PA3 & '0*:7DGMVWc]qb|fhfd`[SIBz8m-`#PDH@` > Z NC *BPC8DEdFlg PPPNLIC3!).2686f2I.0)! 34@x : r Z QC *BPC8DEdFlg PPPPLHC3! ).2686h2K.2)!34@s: r HB YC C g x < y HB ZC C g <  HB \C C g s< t HB ]C C g <  HB cC C g s < t HB dC C g <  HB fC C g o< p HB gC C g <  @@ o   Co   C BeCDE0F@%  eUUSSRPNJHD@{<q9j5b/Z)S%K E=8 2.($!  !&,%4+:1A7I<QBZFbLlPsS}WY]_aceee z s%m)e/]5V9N<F@=D5H,J"NPRSSUUeeeca_]Y(W1S;PELLFVB_<g7o1v+~% ", 5$=(F,N2V6];eAmGsMzRX`fmu{}umf^VOGA;~4v.o(g$]VLE;1 ( {u!m$f(`.X2R8M=GEAK;S6Z2b,j(q${  }slb$Z(Q.I4A;:A4G,O&V!^fmu }  @`@`@`@`o   C BcCDE0F@%  cSSSQPNLJFD@{<q8j3b/Z)S#KE=8 2.($! !&,#4):1A7I<Q@ZFbJlNsQ}UY[_aaccc zs#m)e/]3V8N<F@=D5F,J"LNPQSSScccaa_[Y(U1Q;NEJLFV@_<g7o1v)~#", 5$=(F,N0V5]9e?mEsKzRX^eks{|ukc\TLG?9~4v.o(g"]VLE; 1 ({s!k$e(^.X2R8K=EE?K9S5Z0b,j(q${  }slb"Z(Q.I4A9:?4G,L&T!\cku |  @`@`@`@`j  ?l A  C)Ay ,$D 0 )C <Y  T^ wprobe-derived chemical library:& G   C B CEDE<FJ1 E1 "1 Ea a ((EE"$@`@`@`AX C PBC%DEF(o??%#! ! iT?.&       $,=Rg~  @`Kg  C PBC%DEF(o??%#! ! jU@.'       %,>Sh  @`   C PBC%DEF(o??%#! ! iR?.&       $,=Rh  @`   C PBC%DEF(o??%#!! kTA0(        &.?Ti  @`> \  C PBC%DEF(o??%#!! lUB0)!      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HB ^C C g x < y HB aC C g  < HB bC C g  < HB eC C g <  HB hC C g <   /C <}  ( {  jdisease phenotype:&Gv"l   Cc ,$D 0 *C <$  7 ]probe&G +C <  { _disease&G ,C <$  w"$  Y-&G -C <l  2ww$  Y+&G 0C <   U  `activity& G  1C <  G   `profile:& G H kC C  >D   lC BCFDEF ((  F@@F@FF@@ <<F F@ FF@ F @@  Y\@`@`@`@`@`@`@`@`4@   nC B"C7DEF ))77620 *&$  """   sY@+  $ &*+0@2Y6s77TX@`s D  oC B$C DEDFN  X *  *X$ $(@`" / P wC B"C$DEdFn $"  "  Y+  +Y"$48@`s  P xC B$C$DEdFn $X"*  *X  $  "$48@`  P C B"C$DEdFn $"  "  Y+  +Y"$48@`sh  P C B$C$DEdFn $X"*  *X  $  "$48@`h  P C B"C%DEdFn %#  "  Y+  +Y#%48@`s( M P C B$C%DEdFn %X#*  *X  $  #%48@`( M P C B"C%DEdFn %#  "   Y+  +Y#%48@`s  P C B$C%DEdFn %X#*   *X   $  #%48@`  P C B"C$DEdFn $"  "   Y+  +Y"$48@`s  P C B$C$DEdFn $X"*   *X   $  "$48@`   C BECDE$F0 **Eb"bEb@`@`   C PBC$DEF(o ??$"   ~ iTA.&        $.?Ri~ @`&J C BUCZDEF"Ky ,#U UE#Z,@`Mk0 C BdCjDEF 22.2 :0&.&*.&d\* .`d`dd``RVMVddM`RdMdQ`RdM&f*\\G`R.h&f.h*j&f.h0 02^&f:0:40:op@`@`@`@`@`@`@`@`@`@` Ss C BTCZDEF"Ky T,2 E2ZT,@`Mk0 C BfCjDEF 228@b0X:4 88<@88< RMMRRQMR@f8hR G<\@f@f<j8h@fb0b:@f4^X0b0b0f4b:b0op@`@`@`@`@`@`@`@`@`@`E sH C C 5$ $ XP C xBAC?DEF% A? @` QJ  C 6 ?"0@NNN?N) ,$D  0% C 6 Q,$ 0 3 ... and by chemical genetics + activity profiling:&43G4H @ 0޽h ? LxdRb!X TIMING<|7.8|5.7|9.4|8.4|31|3.1|9|20.8 ___PPT10 .t+ϡD ' = @B D' = @BA?%,( < +O%,( < +D' =%(%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CD' =%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CDs' =%(D' =%(D8' =A@BB BB0B%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CD' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CD' =%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CD' =%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CD' =%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CD+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CD' =%(D' =%(D+' =4@BB BB%(D' =1:Bvisible*o3>+B#style.visibility<*C%(D' =-g6B fade*<3<*CD' =%(D' =%(D8' =A@BB BB0B%(D' =1:Bvisible*o3>+B#style.visibility<*KB%(D' =-g6B fade*<3<*KBD' =%(D' =%(D8' =A@BB BB0B%(D' =1:Bvisible*o3>+B#style.visibility<*IB%(D' =-g6B fade*<3<*IB++0+IB  ++0+KB  ++0+C  + lZK0 ldP!(    T  1 ))?H mTeam & Collaborations  6 8j ,$ 0 %)Group members: Takayuki Shindo (started 1-10-2005) Zhe-Ming Wang (starts 1-12-2005) Farnusch Kaschani (starts 1-1-2006) Current collaborations: Markus Kaiser (CGC, Dortmund) Matt Bogyo (Stanford University, USA) Hermen Overkleeft (Leiden University, NL) Benjamin Cravatt (Scripps Institute, USA)*EEGEGEGEE$!G E$!GE$!GE$!G+# H  0޽h ? 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